S768I Mutation in EGFR in Patients with Lung Cancer.

ABSTRACT:

Introduction

Epidermal growth factor receptor gene (EGFR) mutations are relatively common oncogenic drivers in non-small cell lung cancer (NSCLC). The outcomes of patients who present with less common EGFR mutations or more than one EGFR mutation are uncertain. We reviewed our experience with the S768I mutation of exon 20 of EGFR to provide insight into the clinical significance of this mutation.

Methods

We used a natural language search program to search our electronic medical record system and every EGFR mutation analysis of patients with NSCLC treated at Mayo Clinic that was performed in our Department of Molecular Genetics to identify patients with EGFR S768I mutation. Relevant clinical and laboratory data were abstracted for selected cases, including evaluation of respo

SUBMITTER: Leventakos K 

PROVIDER: S-EPMC5035584 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature