Intrinsic Genomic Differences Between African American and White Patients With Clear Cell Renal Cell Carcinoma.

ABSTRACT:

Importance

There are well-documented racial disparities in outcomes for African American patients with clear cell renal cell carcinoma (ccRCC). Despite a dramatic improvement in overall survival in white patients since the advent of targeted therapy, survival for African Americans with advanced ccRCC has not changed. There is little known about potential racial differences in tumor biology of ccRCC.

Objective

To determine if there are racial differences in the somatic mutation rate and gene expression of ccRCC tumors from white and African American patients.

Design, setting, and participants

Overall, 438 patients with ccRCC were identified through The Cancer Genome Atlas (TCGA) clear cell kidney (KIRC) dataset (419 white and 19 African American patients). The GSE25540

SUBMITTER: Krishnan B 

PROVIDER: S-EPMC5035632 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature