Prognostic role of tumor PIK3CA mutation in colorectal cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Somatic mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway play a vital role in carcinogenesis. Approximately 15%-20% of colorectal cancers (CRCs) harbor activating mutations in PIK3CA, making it one of the most frequently mutated genes in CRC. We thus carried out a systematic review and meta-analysis investigating the prognostic significance of PIK3CA mutations in CRC.

Materials and methods

Electronic databases were searched from inception through May 2015. We extracted the study characteristics and prognostic data of each eligible study. The hazard ratio (HR) and 95% confidence interval (CI) were derived and pooled using the random-effects Mantel-Haenszel model.

Results

Twenty-eight studies enrolling 12 747 patients were eligible

SUBMITTER: Mei ZB 

PROVIDER: S-EPMC5035784 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature