Ultrafast anisotropic protein quake propagation after CO photodissociation in myoglobin.

ABSTRACT: "Protein quake" denotes the dissipation of excess energy across a protein, in response to a local perturbation such as the breaking of a chemical bond or the absorption of a photon. Femtosecond time-resolved small- and wide-angle X-ray scattering (TR-SWAXS) is capable of tracking such ultrafast protein dynamics. However, because the structural interpretation of the experiments is complicated, a molecular picture of protein quakes has remained elusive. In addition, new questions arose from recent TR-SWAXS data that were interpreted as underdamped oscillations of an entire protein, thus challenging the long-standing concept of overdamped global protein dynamics. Based on molecular-dynamics simulations, we present a detailed molecular movie of the protein quake after carbon monoxide (CO) phot

SUBMITTER: Brinkmann LU 

PROVIDER: S-EPMC5035865 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature