Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis.

ABSTRACT: The PRL phosphatases are oncogenic when overexpressed but their in vivo biological function is less well understood. Previous gene deletion study revealed a role for PRL2 in spermatogenesis. We report here the first knockout mice lacking PRL1, the most related homolog of PRL2. We found that loss of PRL1 does not affect spermatogenesis and reproductive ability of male mice, likely due to functional compensation by the relatively higher expression of PRL2 in the testes. However, PRL1^-/-/PRL2^+/- male mice show testicular atrophy phenotype similar to PRL2^-/- mice. More strikingly, deletion of one PRL1 allele in PRL2^-/- male mice causes complete infertility. Mechanistically, the total level of PRL1 and PRL2 is negatively correlated with the PTEN prote

SUBMITTER: Bai Y 

PROVIDER: S-EPMC5035919 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature