Coffee and cancer risk: A meta-analysis of prospective observational studies.

ABSTRACT: Meta-analyses on coffee and cancer incidence mainly restricted to limited cancers. We carried out a more comprehensive meta-analysis of cohort studies to explore association between coffee and most cancer types. We conducted comprehensive search and summarized relative risk (RR) and 95% confidence intervals for the highest versus lowest coffee intake and cancer using STATA12. We conducted dose-analysis if result suggested significant association. The publication bias was evaluated with begg's and egger's test. Finally, 105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma, with RR 0.69 (95% CI = 0.48-0.99, I² = 73.4%, P = 0.044), 0.87 (95% CI = 0.78-0.96, I² = 2

SUBMITTER: Wang A 

PROVIDER: S-EPMC5036059 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature