Papillary Thyroid Carcinoma: Association Between Germline DNA Variant Markers and Clinical Parameters.

ABSTRACT:

Background

Papillary thyroid cancer (PTC) is reported to be highly heritable in epidemiological studies. Genome-wide association studies (GWAS) have uncovered several variants associated with PTC predisposition. It remains unknown whether these variants might contribute to better clinical stratification of PTC patients.

Methods

In order to assess the usefulness of germline genetic analyses in the management of PTC patients, the genotypes of five variants (rs965513, rs944289, rs116909374, rs2439302, and rs966423) were determined in 1216 PTC patients and 1416 controls. Additionally, the expression of seven genes located close to GWAS variants (PTCSC3, MBIP, NKX2-1, FOXE1, DIRC3, PTCSC2, and NRG1) were measured in 73 PTC paired tumor/normal tissues, respectively. Next, the asso

SUBMITTER: Jendrzejewski J 

PROVIDER: S-EPMC5036310 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature