Evaluation of Nestin Expression in the Developing and Adult Mouse Inner Ear.

ABSTRACT: Adult stem cells are undifferentiated cells with the capacity to proliferate and form mature tissue-specific cell types. Nestin is an intermediate filament protein used to identify cells with stem cell characteristics. Its expression has been observed in a population of cells in developing and adult cochleae. In vitro studies using rodent cochlear tissue have documented the potential of nestin-expressing cells to proliferate and form hair and supporting cells. In this study, nestin coupled to green fluorescent protein (GFP) transgenic mice were used to provide a more complete characterization of the spatial and temporal expression of nestin in the inner ear, from organogenesis to adulthood. During development, nestin is expressed in the spiral ganglion cell region and in multiple cell type

SUBMITTER: Chow CL 

PROVIDER: S-EPMC5036354 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature