Utility of a Phylogenetic Perspective in Structural Analysis of CYP72A Enzymes from Flowering Plants.

ABSTRACT: Plant adaptation to external pressures depends on functional diversity in cytochrome P450 (CYP) enzymes. CYPs contain structural domains necessary for the characteristic P450 fold that allows monooxygenation, but they also have great variation in substrate binding affinity. Plant genomes typically contain hundreds of CYPs that contribute to essential functions and species-specific metabolism. The CYP72A subfamily is conserved in angiosperms but its contribution to physiological functions is largely unknown. With genomic information available for many plants, a focused analysis of CYP subfamily diversity is important to understand the contributions of these enzymes to plant evolution. This study examines the extent to which independent gene duplication and evolution have contributed to stru

SUBMITTER: Prall W 

PROVIDER: S-EPMC5036807 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature