Computational Modeling of Lipid Metabolism in Yeast.

ABSTRACT: Lipid metabolism is essential for all major cell functions and has recently gained increasing attention in research and health studies. However, mathematical modeling by means of classical approaches such as stoichiometric networks and ordinary differential equation systems has not yet provided satisfactory insights, due to the complexity of lipid metabolism characterized by many different species with only slight differences and by promiscuous multifunctional enzymes. Here, we present an object-oriented stochastic model approach as a way to cope with the complex lipid metabolic network. While all lipid species are treated objects in the model, they can be modified by the respective converting reactions based on reaction rules, a hybrid method that integrates benefits of agent-based and cl

SUBMITTER: Schutzhold V 

PROVIDER: S-EPMC5037213 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature