Molecular pathological epidemiology in diabetes mellitus and risk of hepatocellular carcinoma.

ABSTRACT: Molecular pathological epidemiology (MPE) is a multidisciplinary and transdisciplinary study field, which has emerged as an integrated approach of molecular pathology and epidemiology, and investigates the relationship between exogenous and endogenous exposure factors, tumor molecular signatures, and tumor initiation, progression, and response to treatment. Molecular epidemiology broadly encompasses MPE and conventional-type molecular epidemiology. Hepatocellular carcinoma (HCC) is the third most common cause of cancer-associated death worldwide and remains as a major public health challenge. Over the past few decades, a number of epidemiological studies have demonstrated that diabetes mellitus (DM) is an established independent risk factor for HCC. However, how DM affects the occurrence a

SUBMITTER: Gao C 

PROVIDER: S-EPMC5037325 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature