SMAR1 binds to T(C/G) repeat and inhibits tumor progression by regulating miR-371-373 cluster.

ABSTRACT: Chromatin architecture and dynamics are regulated by various histone and non-histone proteins. The matrix attachment region binding proteins (MARBPs) play a central role in chromatin organization and function through numerous regulatory proteins. In the present study, we demonstrate that nuclear matrix protein SMAR1 orchestrates global gene regulation as determined by massively parallel ChIP-sequencing. The study revealed that SMAR1 binds to T(C/G) repeat and targets genes involved in diverse biological pathways. We observe that SMAR1 binds and targets distinctly different genes based on the availability of p53. Our data suggest that SMAR1 binds and regulates one of the imperative microRNA clusters in cancer and metastasis, miR-371-373. It negatively regulates miR-371-373 transcription as

SUBMITTER: Mathai J 

PROVIDER: S-EPMC5037395 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature