Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.

ABSTRACT: On Earth, biological systems have evolved in response to environmental stressors, interactions dictated by physical forces that include gravity. The absence of gravity is an extreme stressor and the impact of its absence on biological systems is ill-defined. Astronauts who have spent extended time under conditions of minimal gravity (microgravity) experience an array of biological alterations, including perturbations in cardiovascular function. We hypothesized that physiological perturbations in cardiac function in microgravity may be a consequence of alterations in molecular and organellar dynamics within the cellular milieu of cardiomyocytes. We used a combination of mass spectrometry-based approaches to compare the relative abundance and turnover rates of 848 and 196 proteins, respectiv

SUBMITTER: Feger BJ 

PROVIDER: S-EPMC5037457 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature