A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification.

ABSTRACT: Severe bioprosthetic mitral valve calcification is a significant problem in cardiovascular surgery. Unfortunately, clinical markers did not demonstrate efficacy in prediction of severe bioprosthetic mitral valve calcification. Here, we examined whether a genomics-based approach is efficient in predicting the risk of severe bioprosthetic mitral valve calcification. A total of 124 consecutive Russian patients who underwent mitral valve replacement surgery were recruited. We investigated the associations of the inherited variation in innate immunity, lipid metabolism and calcium metabolism genes with severe bioprosthetic mitral valve calcification. Genotyping was conducted utilizing the TaqMan assay. Eight gene polymorphisms were significantly associated with severe bioprosthetic mitral valve

SUBMITTER: Ponasenko AV 

PROVIDER: S-EPMC5037665 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature