Melanoma Brain Metastasis: Mechanisms, Models, and Medicine.

ABSTRACT: The development of brain metastases in patients with advanced stage melanoma is common, but the molecular mechanisms responsible for their development are poorly understood. Melanoma brain metastases cause significant morbidity and mortality and confer a poor prognosis; traditional therapies including whole brain radiation, stereotactic radiotherapy, or chemotherapy yield only modest increases in overall survival (OS) for these patients. While recently approved therapies have significantly improved OS in melanoma patients, only a small number of studies have investigated their efficacy in patients with brain metastases. Preliminary data suggest that some responses have been observed in intracranial lesions, which has sparked new clinical trials designed to evaluate the efficacy in melanoma

SUBMITTER: Kircher DA 

PROVIDER: S-EPMC5037746 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature