Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study.

ABSTRACT:

Background

In patients with asthma, the fungus Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis (ABPA). Familial ABPA is reported, and some genetic factors have been associated with the disease, however, these are small studies (n ≤ 38) and do not explain all cases of ABPA.

Methods

We analysed SNPs in 95 ABPA patients, comparing frequencies to 152 atopic asthmatic and 279 healthy controls. Twenty two genes were selected from literature, and 195 tagging SNPs were analysed for genetic association with ABPA using logistic regression corrected for multiple testing. We also analysed monocyte-derived macrophage gene expression before and during co-culture with A. fumigatus.

Results

Seventeen ABPA-associated SNPs (ABPA v Atopic asthma) we

SUBMITTER: Overton NL 

PROVIDER: S-EPMC5037889 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature