Identification and Characterization of a Putative Manganese Export Protein in Vibrio cholerae.

ABSTRACT:

Unlabelled

Manganese plays an important role in the cellular physiology and metabolism of bacterial species, including the human pathogen Vibrio cholerae The intracellular level of manganese ions is controlled through coordinated regulation of the import and export of this element. We have identified a putative manganese exporter (VC0022), named mneA (manganese exporter A), which is highly conserved among Vibrio spp. An mneA mutant exhibited sensitivity to manganese but not to other cations. Under high-manganese conditions, the mneA mutant showed an almost 50-fold increase in intracellular manganese levels and reduced intracellular iron relative to those of its wild-type parent, suggesting that the mutant's manganese sensitivity is due to the accumulation of toxic levels of mangane

SUBMITTER: Fisher CR 

PROVIDER: S-EPMC5038002 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature