MgtC as a Host-Induced Factor and Vaccine Candidate against Mycobacterium abscessus Infection.

ABSTRACT: Mycobacterium abscessus is an emerging pathogenic mycobacterium involved in pulmonary and mucocutaneous infections, presenting a serious threat for patients with cystic fibrosis (CF). The lack of an efficient treatment regimen and the emergence of multidrug resistance in clinical isolates require the development of new therapeutic strategies against this pathogen. Reverse genetics has revealed genes that are present in M. abscessus but absent from saprophytic mycobacteria and that are potentially involved in pathogenicity. Among them, MAB_3593 encodes MgtC, a known virulence factor involved in intramacrophage survival and adaptation to Mg(2+) deprivation in several major bacterial pathogens. Here, we demonstrated a strong induction of M. abscessus MgtC at both the transcriptional and trans

SUBMITTER: Le Moigne V 

PROVIDER: S-EPMC5038086 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature