MiRNA-335 and miRNA-182 affect the occurrence of tongue squamous cell carcinoma by targeting survivin.

ABSTRACT: The aim of the present study was to characterize the roles of two microRNAs (miRs) that have been reported to be differentially expressed in tongue squamous cell carcinoma (TSCC), miR-335 and miR-182. In total, 20 tumor tissue samples and 20 corresponding adjacent non-cancerous samples were collected from patients with TSCC to measure the expression of miR-335 and miR-182 and the potential shared target of these miRs, survivin, using reverse transcription-quantitative polymerase chain reaction and western blotting. In the TSCC tissue samples, significantly decreased expression of the two miRs and increased expression of survivin were detected compared with adjacent non-cancerous controls. Subsequently, it was confirmed that survivin was the target gene of miR-335 and miR-182 using a lucife

SUBMITTER: Ou D 

PROVIDER: S-EPMC5038158 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature