Impact of different aortic valve calcification patterns on the outcome of transcatheter aortic valve implantation: A finite element study.

ABSTRACT: Transcatheter aortic valve implantation (TAVI) can treat symptomatic patients with calcific aortic stenosis. However, the severity and distribution of the calcification of valve leaflets can impair the TAVI efficacy. Here we tackle this issue from a biomechanical standpoint, by finite element simulation of a widely adopted balloon-expandable TAVI in three models representing the aortic root with different scenarios of calcific aortic stenosis. We developed a modeling approach realistically accounting for aortic root pressurization and complex anatomy, detailed calcification patterns, and for the actual stent deployment through balloon-expansion. Numerical results highlighted the dependency on the specific calcification pattern of the "dog-boning" of the stent. Also, local stent distortions

SUBMITTER: Sturla F 

PROVIDER: S-EPMC5038160 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature