Study of cardiovascular function using a coupled left ventricle and systemic circulation model.

ABSTRACT: To gain insight into cardio-arterial interactions, a coupled left ventricle-systemic artery (LV-SA) model is developed that incorporates a three-dimensional finite-strain left ventricle (LV), and a physiologically-based one-dimensional model for the systemic arteries (SA). The coupling of the LV model and the SA model is achieved by matching the pressure and the flow rate at the aortic root, i.e. the SA model feeds back the pressure as a boundary condition to the LV model, and the aortic flow rate from the LV model is used as the input for the SA model. The governing equations of the coupled system are solved using a combined immersed-boundary finite-element (IB/FE) method and a Lax-Wendroff scheme. A baseline case using physiological measurements of healthy subjects, and four exemplar cas

SUBMITTER: Chen WW 

PROVIDER: S-EPMC5038162 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature