Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms.

ABSTRACT: It is now well established that bacterial infections are often associated with biofilm phenotypes that demonstrate increased resistance to common antimicrobials. Further, due to the collective attrition of new antibiotic development programs by the pharmaceutical industries, drug repurposing is an attractive alternative. In this work, we screened 1,280 existing commercially available drugs in the Prestwick Chemical Library, some with previously unknown antimicrobial activity, against Staphylococcus aureus, one of the commonly encountered causative pathogens of burn and wound infections. From the primary screen of the entire Prestwick Chemical Library at a fixed concentration of 10 μM, 104 drugs were found to be effective against planktonic S. aureus strains, and not surprisingly, these wer

SUBMITTER: Torres NS 

PROVIDER: S-EPMC5038268 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature