Transcription factor 4 gene rs9960767 polymorphism in bipolar disorder.

ABSTRACT: The transcription factor 4 (TCF4) gene encodes a helix-loop-helix transcription factor protein, which initiates neuronal differentiation and is primarily expressed during nervous system development. The aim of the present study is to investigate the association of the TCF4 rs9960767 polymorphism and bipolar disorder, which is highly heritable. DNA isolation was performed on 95 patients with bipolar disorder and 108 healthy control subjects to examine the TCF4 rs9960767 polymorphism. Genotypic and allelic frequencies were determined using the polymerase chain reaction-restriction fragment length polymorphism method designed in our laboratory. Statistical analysis was performed using χ² test within the 95% confidence interval. Odds ratios were calculated and Hardy-Weinberg equilib

SUBMITTER: Ozel MD 

PROVIDER: S-EPMC5038469 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature