M2SR, a novel live single replication influenza virus vaccine, provides effective heterosubtypic protection in mice.

ABSTRACT: Despite the annual public health burden of seasonal influenza and the continuing threat of a global pandemic posed by the emergence of highly pathogenic/pandemic strains, conventional influenza vaccines do not provide universal protection, and exhibit suboptimal efficacy rates, even when they are well matched to circulating strains. To address the need for a highly effective universal influenza vaccine, we have developed a novel M2-deficient single replication vaccine virus (M2SR) that induces strong cross-protective immunity against multiple influenza strains in mice. M2SR is able to infect cells and expresses all viral proteins except M2, but is unable to generate progeny virus. M2SR generated from influenza A/Puerto Rico/8/34 (H1N1) protected mice against lethal challenge with influenza

SUBMITTER: Sarawar S 

PROVIDER: S-EPMC5038585 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature