A genome-wide investigation of food addiction.

ABSTRACT:

Objective

Evidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction. It was hypothesized that a genome-wide association study (GWAS) of food addiction would yield significant enrichment in genes and pathways linked to addiction.

Methods

A GWAS of food addiction, determined by the modified Yale Food Addiction Scale (mYFAS), was conducted among 9,314 women of European ancestry, and results for enrichment of single-nucleotide polymorphisms (SNPs) (n = 44), genes (n = 238), and pathways (n = 11) implicated in drug addiction were examined.

Results

Two loci met GW-significance (P < 2.5 ×

SUBMITTER: Cornelis MC 

PROVIDER: S-EPMC5038917 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature