Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration.

ABSTRACT: Liver regeneration is a well-orchestrated process in the liver that allows mature hepatocytes to reenter the cell cycle to proliferate and replace lost or damaged cells. This process is often impaired in fatty or diseased livers, leading to cirrhosis and other deleterious phenotypes. Prior research has established the role of the complement system and its effector proteins in the progression of liver regeneration; however, a detailed mechanistic understanding of the involvement of complement in regeneration is yet to be established. In this study, we have examined the role of the complement system during the priming phase of liver regeneration through a systems level analysis using a combination of transcriptomic and metabolomic measurements. More specifically, we have performed partial he

SUBMITTER: Min JS 

PROVIDER: S-EPMC5038987 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature