Fibrous Dysplasia and Medication-Related Osteonecrosis of the Jaw.

ABSTRACT:

Purpose

Osteonecrosis of the jaw (ONJ) is an established side effect of intravenous bisphosphonates and other antiresorptive medications. Although bisphosphonates are frequently prescribed for patients with the skeletal disorder fibrous dysplasia (FD), there are no reports of ONJ in this population. This has led some to conclude that patients with FD are at low risk for the development of bisphosphonate-related ONJ.

Patients and methods

Patients were evaluated as part of a longstanding FD natural history study at the National Institutes of Health.

Results

Of 76 patients with FD who were treated with bisphosphonates, 4 developed ONJ (5.4%). Three patients developed ONJ in areas of FD-affected bone and 1 in an area of normal bone. All 4 patients had features known to be

SUBMITTER: Metwally T 

PROVIDER: S-EPMC5039058 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature