Progression of Brain Network Alterations in Cerebral Amyloid Angiopathy.

ABSTRACT:

Background and purpose

We recently showed that cerebral amyloid angiopathy (CAA) is associated with functionally relevant brain network impairments, in particular affecting posterior white matter connections. Here we examined how these brain network impairments progress over time.

Methods

Thirty-three patients with probable CAA underwent multimodal brain magnetic resonance imaging at 2 time points (mean follow-up time: 1.3±0.4 years). Brain networks of the hemisphere free of intracerebral hemorrhages were reconstructed using fiber tractography and graph theory. The global efficiency of the network and mean fractional anisotropies of posterior-posterior, frontal-frontal, and posterior-frontal network connections were calculated. Patients with moderate versus severe CAA were d

SUBMITTER: Reijmer YD 

PROVIDER: S-EPMC5039080 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature