New Genes Involved in Osmotic Stress Tolerance in Saccharomyces cerevisiae.

ABSTRACT: Adaptation to changes in osmolarity is fundamental for the survival of living cells, and has implications in food and industrial biotechnology. It has been extensively studied in the yeast Saccharomyces cerevisiae, where the Hog1 stress activated protein kinase was discovered about 20 years ago. Hog1 is the core of the intracellular signaling pathway that governs the adaptive response to osmotic stress in this species. The main endpoint of this program is synthesis and intracellular retention of glycerol, as a compatible osmolyte. Despite many details of the signaling pathways and yeast responses to osmotic challenges have already been described, genome-wide approaches are contributing to refine our knowledge of yeast adaptation to hypertonic media. In this work, we used a quantitat

SUBMITTER: Gonzalez R 

PROVIDER: S-EPMC5039201 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature