Prefrontal Cortex Networks Shift from External to Internal Modes during Learning.

ABSTRACT:

Unlabelled

As we learn about items in our environment, their neural representations become increasingly enriched with our acquired knowledge. But there is little understanding of how network dynamics and neural processing related to external information changes as it becomes laden with "internal" memories. We sampled spiking and local field potential activity simultaneously from multiple sites in the lateral prefrontal cortex (PFC) and the hippocampus (HPC)-regions critical for sensory associations-of monkeys performing an object paired-associate learning task. We found that in the PFC, evoked potentials to, and neural information about, external sensory stimulation decreased while induced beta-band (∼11-27 Hz) oscillatory power and synchrony associated with "top-down" or internal

SUBMITTER: Brincat SL 

PROVIDER: S-EPMC5039250 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature