Correia Repeat Enclosed Elements and Non-Coding RNAs in the Neisseria Species.

ABSTRACT: Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. Neisseria meningitidis is a closely related pathogen that shares many of the same genomic features and virulence factors, but causes the life threatening diseases meningococcal meningitis and septicaemia. The importance of non-coding RNAs in gene regulation has become increasingly evident having been demonstrated to be involved in regulons responsible for iron acquisition, antigenic variation, and virulence. Neisseria spp. contain an IS-like element, the Correia Repeat Enclosed Element, which has been predicted to be mobile within the genomes or to have been in the past. This repeat, present in over 100 copies in the genome, has the ability to alter gene expression and regulation in several

SUBMITTER: Roberts SB 

PROVIDER: S-EPMC5039591 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature