Genetic influence on circulating vitamin D among Saudi Arabians.

ABSTRACT:

Objectives

 To examine the effect of most common studied single nucleotide polymorphisms (SNP) on serum 25-hydroxyvitamin D (25OHD) levels in Saudi Arabian population. 

Method

A cross-sectional observational study was carried out between July 2014 and October 2015, at King Fahd Hospital of the University (KFHU), Al-Khobar, Kingdom of Saudi Arabia. After informed consent, blood samples from 283 subjects living in the Eastern province were collected for 25-OHD measurement and genetic analysis of SNPs in vitamin D receptor (VDR) [rs2228570 and rs1544410], Cytochrome, P450 family 2 (CYP2R1) [rs10741657 and rs1993116], and Group-specific components (GC) [rs2282679 and rs4588]. 

Results

Vitamin D deficiency was found in 87.6% and insufficiency in 7.7%. The percentages of th

SUBMITTER: Sadat-Ali M 

PROVIDER: S-EPMC5039620 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature