Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass.

ABSTRACT: Ataxia-telangiectasia mutated (ATM) kinase is a central component involved in the signal transduction of the DNA damage response (DDR) and thus plays a critical role in the maintenance of genomic integrity. Although the primary functions of ATM are associated with the DDR, emerging data suggest that ATM has many additional roles that are not directly related to the DDR, including the regulation of oxidative stress signaling, insulin sensitivity, mitochondrial homeostasis, and lymphocyte development. Patients and mice lacking ATM exhibit growth retardation and lower bone mass; however, the mechanisms underlying the skeletal defects are not fully understood. In the present study, we generated mutant mice in which ATM is specifically inactivated in osteoclasts. The mutant mice did not exhibit

SUBMITTER: Hirozane T 

PROVIDER: S-EPMC5039636 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature