Simulating the Evolution of Functional Brain Networks in Alzheimer's Disease: Exploring Disease Dynamics from the Perspective of Global Activity.

ABSTRACT: Functional brain connectivity is altered during the pathological processes of Alzheimer's disease (AD), but the specific evolutional rules are insufficiently understood. Resting-state functional magnetic resonance imaging indicates that the functional brain networks of individuals with AD tend to be disrupted in hub-like nodes, shifting from a small world architecture to a random profile. Here, we proposed a novel evolution model based on computational experiments to simulate the transition of functional brain networks from normal to AD. Specifically, we simulated the rearrangement of edges in a pathological process by a high probability of disconnecting edges between hub-like nodes, and by generating edges between random pair of nodes. Subsequently, four topological properties and a nodal

SUBMITTER: Li W 

PROVIDER: S-EPMC5039719 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature