Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.

ABSTRACT: Cytosine methylation of DNA is an epigenetic modification involved in the repression of genes that affect biological processes including hematopoiesis. It is catalyzed by DNA methyltransferases, one of which -DNMT3A- is frequently mutated in human hematologic malignancies. We have previously reported that Dnmt3a inactivation in hematopoietic stem cells results in chronic lymphocytic leukemia (CLL) and CD8-positive peripheral T cell lymphomas (PTCL) in EμSRα-tTA;Teto-Cre;Dnmt3a^fl/fl; Rosa26LOXP^EGFP/EGFP (Dnmt3a^Δ/Δ) mice. The extent to which molecular changes overlap between these diseases is not clear. Using high resolution global methylation and expression analysis we show that whereas patterns of methylation and transcription in normal B-1a cells and CD8-p

SUBMITTER: Haney SL 

PROVIDER: S-EPMC5039761 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature