Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

ABSTRACT:

Background

Elevated serum calcium has been associated with a variety of metabolic abnormalities and may be associated with a greater risk of diabetes.

Objective

The purpose of this study was to test the hypothesis that serum calcium concentration is positively and independently associated with the incidence of diabetes and to evaluate the association of calcium-sensing receptor (CaSR) gene single nucleotide polymorphism (SNP) rs1801725 with incident diabetes.

Design

Atherosclerosis Risk in Communities study participants free of diabetes at baseline (n = 12,800; mean age: 53.9 y; 22.6% black) were studied for incident diabetes. Serum calcium was measured at baseline and corrected for serum albumin. Diabetes was defined by use of glucose concentrations, self-report, or

SUBMITTER: Rooney MR 

PROVIDER: S-EPMC5039808 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature