A drug target slim: using gene ontology and gene ontology annotations to navigate protein-ligand target space in ChEMBL.

ABSTRACT:

Background

The process of discovering new drugs is a lengthy, time-consuming and expensive process. Modern day drug discovery relies heavily on the rapid identification of novel 'targets', usually proteins that can be modulated by small molecule drugs to cure or minimise the effects of a disease. Of the 20,000 proteins currently reported as comprising the human proteome, just under a quarter of these can potentially be modulated by known small molecules Storing information in curated, actively maintained drug discovery databases can help researchers access current drug discovery information quickly. However with the increase in the amount of data generated from both experimental and in silico efforts, databases can become very large very quickly and information retrieval from them

SUBMITTER: Mutowo P 

PROVIDER: S-EPMC5039825 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature