An efficient method for protein function annotation based on multilayer protein networks.

ABSTRACT:

Background

Accurate annotation of protein functions is still a big challenge for understanding life in the post-genomic era. Many computational methods based on protein-protein interaction (PPI) networks have been proposed to predict the function of proteins. However, the precision of these predictions still needs to be improved, due to the incompletion and noise in PPI networks. Integrating network topology and biological information could improve the accuracy of protein function prediction and may also lead to the discovery of multiple interaction types between proteins. Current algorithms generate a single network, which is archived using a weighted sum of all types of protein interactions.

Method

The influences of different types of interactions on the prediction of prot

SUBMITTER: Zhao B 

PROVIDER: S-EPMC5039885 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature