The effect of mesenchymal stromal cell sheets on the inflammatory stage of flexor tendon healing.

ABSTRACT:

Background

The clinical outcomes following intrasynovial flexor tendon repair are highly variable. Excessive inflammation is a principal factor underlying the formation of adhesions at the repair surface and affecting matrix regeneration at the repair center that limit tendon excursion and impair tendon healing. A previous in-vitro study revealed that adipose-derived mesenchymal stromal cells (ASCs) modulate tendon fibroblast response to macrophage-induced inflammation. The goal of the current study was therefore to explore the effectiveness of autologous ASCs on the inflammatory stage of intrasynovial tendon healing in vivo using a clinically relevant animal model.

Methods

Zone II flexor tendon transections and suture repairs were performed in a canine model. Autologous ASC

SUBMITTER: Shen H 

PROVIDER: S-EPMC5039894 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature