A comparative study on the regulatory region of the PERIOD1 gene among diurnal/nocturnal primates.

ABSTRACT:

Background

The circadian clock is set up around a 24-h period in humans who are awake in the daytime and sleep in the nighttime, accompanied with physiological and metabolic rhythms. Most haplorhine primates, including humans, are diurnal, while most "primitive" strepsirrhine primates are nocturnal, suggesting primates have evolved from nocturnal to diurnal habits. The mechanisms of physiological changes causing the habits and of genetic changes causing the physiological changes are, however, unknown. To reveal these mechanisms, we focus on the nucleotide sequences of the regulatory region of the PERIOD1 (PER1) gene that is known as one of the key elements of the circadian clock in mammalians.

Methods

We determined nucleotide sequences of the regulatory region of PER1 concer

SUBMITTER: Katsumura T 

PROVIDER: S-EPMC5039903 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature