Central obesity increases risk of breast cancer irrespective of menopausal and hormonal receptor status in women of South Asian Ethnicity.

ABSTRACT:

Background

Current evidence suggests that the relationship between obesity and breast cancer (BC) risk may vary between ethnic groups.

Methods

A total of 1633 BC cases and 1504 controls were enrolled in hospital-based case-control study in Mumbai, India, from 2009 to 2013. Along with detailed questionnaire, we collected anthropometric measurements on all participants. We used unconditional logistic regression models to estimate odds ratios (ORs) and 95% confidence interval (CI) for BC risk associated with anthropometry measurements, stratified on tumour subtype and menopausal status.

Results

Waist-to-hip ratio (WHR) of ≥0.95 was strongly associated with risk of BC compared to WHR ≤0.84 in both premenopausal (OR = 4.3; 95% CI: 2.9-6.3) and postmenopausal women (OR = 3.

SUBMITTER: Nagrani R 

PROVIDER: S-EPMC5040194 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature