Airway factor XIII associates with type 2 inflammation and airway obstruction in asthmatic patients.

ABSTRACT:

Background

Coagulation Factor XIII (FXIII) plays an important role in wound healing by stabilizing fibrin clots and cross-linking extracellular matrix proteins. FXIII is expressed in cells of the monocyte/macrophage and dendritic cell lineages in response to type 2 cytokines.

Objective

We sought to determine the association between FXIII and asthma pathobiology.

Methods

We analyzed the expression of FXIII mRNA and protein levels in bronchoalveolar lavage samples obtained before and after segmental allergen challenge from patients with mild asthma and in induced sputum samples collected from patients with mild-to-moderate and severe asthma.

Results

FXIII mRNA and protein levels were highly upregulated in bronchoalveolar cells and fluid after allergen challenge a

SUBMITTER: Esnault S 

PROVIDER: S-EPMC5040212 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature