Heteronuclear cross-relaxation effects in the NMR spectroscopy of hyperpolarized targets.

ABSTRACT: Dissolution dynamic nuclear polarization (DNP) enables high-sensitivity solution-phase NMR experiments on long-lived nuclear spin species such as (15)N and (13)C. This report explores certain features arising in solution-state (1)H NMR upon polarizing low-γ nuclear species. Following solid-state hyperpolarization of both (13)C and (1)H, solution-phase (1)H NMR experiments on dissolved samples revealed transient effects, whereby peaks arising from protons bonded to the naturally occurring (13)C nuclei appeared larger than the typically dominant (12)C-bonded (1)H resonances. This enhancement of the satellite peaks was examined in detail with respect to a variety of mechanisms that could potentially explain this observation. Both two- and three-spin phenomena active in the solid state could l

SUBMITTER: Donovan KJ 

PROVIDER: S-EPMC5040509 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature