Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis.

ABSTRACT: Since the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological processes. How this post-transcriptional RNA-regulatory machine impacts cell fate decisions and differentiation is poorly understood. Previously, we demonstrated that exosome complex subunits confer an erythroid maturation barricade, and the erythroid transcription factor GATA-1 dismantles the barricade by transcriptionally repressing the cognate genes. While dissecting requirements for the maturation barricade in Mus musculus, we discovered that the exosome complex is a vital determinant of a developmental signaling transition that dictates proliferation/amplification versus differentiation. Exosome complex integrity in eryt

SUBMITTER: McIver SC 

PROVIDER: S-EPMC5040589 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature