Multiband spectral-spatial RF excitation for hyperpolarized [2-¹³ C]dihydroxyacetone ¹³ C-MR metabolism studies.

ABSTRACT:

Purpose

To develop a specialized multislice, single-acquisition approach to detect the metabolites of hyperpolarized (HP) [2-¹³ C]dihydroxyacetone (DHAc) to probe gluconeogenesis in vivo, which have a broad 144 ppm spectral range (∼4.6 kHz at 3T). A novel multiband radio-frequency (RF) excitation pulse was designed for independent flip angle control over five to six spectral-spatial (SPSP) excitation bands, each corrected for chemical shift misregistration effects.

Methods

Specialized multiband SPSP RF pulses were designed, tested, and applied to investigate HP [2-¹³ C]DHAc metabolism in kidney and liver of fasted rats with dynamic ¹³ C-MR spectroscopy and an optimal flip angle scheme. For comparison, experiments were also performed with narr

SUBMITTER: Marco-Rius I 

PROVIDER: S-EPMC5040611 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature