MgaSpn and H-NS: Two Unrelated Global Regulators with Similar DNA-Binding Properties.

ABSTRACT: Global regulators play an essential role in the adaptation of bacterial cells to specific niches. Bacterial pathogens thriving in the tissues and organs of their eukaryotic hosts are a well-studied example. Some of the proteins that recognize local DNA structures rather than specific nucleotide sequences act as global modulators in many bacteria, both Gram-negative and -positive. To this class of regulators belong the H-NS-like proteins, mainly identified in γ-Proteobacteria, and the MgaSpn-like proteins identified in Firmicutes. H-NS and MgaSpn from Escherichia coli and Streptococcus pneumoniae, respectively, neither have sequence similarity nor share structural domains. Nevertheless, they display common features in their interaction with DNA, namely: (i) they

SUBMITTER: Solano-Collado V 

PROVIDER: S-EPMC5040716 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature