Genome Diversity, Recombination, and Virulence across the Major Lineages of Paracoccidioides.

ABSTRACT: The Paracoccidioides genus includes two species of thermally dimorphic fungi that cause paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic to Latin America. To examine the genome evolution and the diversity of Paracoccidioides spp., we conducted whole-genome sequencing of 31 isolates representing the phylogenetic, geographic, and ecological breadth of the genus. These samples included clinical, environmental and laboratory reference strains of the S1, PS2, PS3, and PS4 lineages of P. brasiliensis and also isolates of Paracoccidioides lutzii species. We completed the first annotated genome assemblies for the PS3 and PS4 lineages and found that gene order was highly conserved across the major lineages, with only a few chro

SUBMITTER: Munoz JF 

PROVIDER: S-EPMC5040785 | biostudies-literature | 2016 Sep-Oct

REPOSITORIES: biostudies-literature