Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.

ABSTRACT: Mutations in the p53 tumor-suppressor gene are prevalent in human cancers. The majority of p53 mutations are missense, which can be classified into contact mutations (that directly disrupts the DNA-binding activity of p53) and structural mutations (that disrupts the conformation of p53). Both of the mutations can disable the normal wild-type (WT) p53 activities. Nevertheless, it has been amply documented that small molecules can rescue activity from mutant p53 by restoring WT tumor-suppressive functions. These compounds hold promise for cancer therapy and have now entered clinical trials. In this study, we show that cruciferous-vegetable-derived phenethyl isothiocyanate (PEITC) can reactivate p53 mutant under in vitro and in vivo conditions, revealing a new mechanism of action for a dietar

SUBMITTER: Aggarwal M 

PROVIDER: S-EPMC5041190 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature