Association between polymorphisms of OGG1, EPHA2 and age-related cataract risk: a meta-analysis.

ABSTRACT:

Background

Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and eph-receptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. However, the results were not consistent. The objective of this study was to examine the role of these two gene polymorphisms in ARC susceptibility.

Methods

Eligible case-control studies published between January 2000 and 2015 were searched and retrieved in the electronic databases. The odds ratio with 95 % confidence interval (CI) was employed to calculate the strength of the relationship.

Results

We totally screened out six articles, including 5971 cataract patients and 4189 matched controls. Three variants were contained (OGG1 rs1052133; EPHA2 rs7543472 and rs11260867). For O

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5041552 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature