Role of NF-kβ factor Rel2 during Plasmodium falciparum and bacterial infection in Anopheles dirus.

ABSTRACT:

Background

Anopheles mosquitoes transmit malaria which is one of the world's most threatening diseases. Anopheles dirus (sensu stricto) is among the main vectors of malaria in South East Asia. The mosquito innate immune response is the first line of defence against malaria parasites during its development. The immune deficiency (IMD) pathway, a conserved immune signaling pathway, influences anti-Plasmodium falciparum activity in Anopheles gambiae, An. stephensi and An. albimanus. The aim of the study was to determine the role of Rel2, an IMD pathway-controlled NF-kappaβ transcription factor, in An. dirus.

Methods

RACE (Rapid amplification of cDNA ends) was performed on the Rel2 gene. Double-stranded Rel2 was constructed and injected into the thorax of female mosquitoes. The

SUBMITTER: Khan MB 

PROVIDER: S-EPMC5041562 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature